Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA.

Acute promyelocytic leukemia (APL) is a unique disease entity in acute myeloid leukemia, characterized by PML-RARA fusion gene, which is generated by chromosomal translocation t(15;17)(q24;q21). We identified TNRC18-RARA as novel RARA fusion in resembling APL. Our study highlights the importance of combining multiple molecular techniques to characterize and optimally manage APL lacking classic t(15;17)(q24;q12)/PML-RARA fusion. © 2021 Wiley Periodicals LLC.

Citation

Zheng Wang, Lijun Wen, Ling Zhang, Xiaoyu Xu, Xiaoqian Chen, Li Yao, Man Wang, Zhen Shen, Guangquan Mo, Yao Wang, Dewan Zhao, Wei Cai, Jingzhi Shen, Xiaomeng Chi, Yi Xu, Zhao Zeng, Jinlan Pan, Changgeng Ruan, Depei Wu, Zhilin Jia, Suning Chen. Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA. Molecular carcinogenesis. 2021 Feb;60(2)

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PMID: 33428799

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