Immunostimulatory and anti-allergic potential of novel heterotrimeric lectin from seeds of Zizyphus mauritiana Lam.

Ashwin B Butle, Suhas A Talmale, Vivek V Jadhao, Mandakini B Patil, Trimurti L Lambat

International journal of biological macromolecules 2021 Feb 28

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Zizyphus mauritiana Lam. seeds (ZMS) have been used medicinally as sedative or hypnotic drugs in most of Asian countries. ZMS has significant benefits to the human health. Therefore, we have evaluated immunomodulatory effect of lectin extracted from these ZMSL in both in vitro and in vivo study. Anaphylaxis is a severe life-threatening allergic reaction and Arthus reaction is deposition of immune complex and complement system activation, so we hypothesized that if ZMSL can protect these severe allergic diseases. We have studied the effect of ZMSL on macrophages and Wistar albino rats and confirmed its protective effect against anaphylaxis and Arthus reaction. Results of this study suggest ZMSL have immunostimulatory and antiallergic activity. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Ashwin B Butle, Suhas A Talmale, Vivek V Jadhao, Mandakini B Patil, Trimurti L Lambat. Immunostimulatory and anti-allergic potential of novel heterotrimeric lectin from seeds of Zizyphus mauritiana Lam. International journal of biological macromolecules. 2021 Feb 28;171:389-397