Deep and Durable Response After Discontinuation of Nivolumab/Ipilimumab Combination Therapy for Metastatic Renal Cell Carcinoma : A Case Report].

Masafumi Tsuruta, Noboru Shibasaki, Ryo Iguch, Takahiro Yamaguchi, Hideto Ota, Yasushi Fuchigami, Toshihiro Magaribuchi, Hirohito Naito, Akito Terai

Hinyokika kiyo. Acta urologica Japonica 2020 Dec

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A 47-year-old man was referred to our hospital for epigastric pain and cough, and was given a diagnosis of left clear cell renal carcnoma with multiple pulmonary metastases based on the results of renal tumor biopsy (cT3aN0M1). He received nivolumab/ipilimumab combination therapy, but developed diarrhea (grade 3) on day71, and treatment was discontinued. However, a deep and durable response after discontinuation of treatment was shown, and we were able to perform nephrectomy on day336. He is undergoing nivolumab therapy for pulmonary metastases.

Citation

Masafumi Tsuruta, Noboru Shibasaki, Ryo Iguch, Takahiro Yamaguchi, Hideto Ota, Yasushi Fuchigami, Toshihiro Magaribuchi, Hirohito Naito, Akito Terai. Deep and Durable Response After Discontinuation of Nivolumab/Ipilimumab Combination Therapy for Metastatic Renal Cell Carcinoma : A Case Report]. Hinyokika kiyo. Acta urologica Japonica. 2020 Dec;66(12):443-448