Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions.

Bo Wang, Ying Huang

Lasers in medical science 2022 Feb

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Immunotherapy of tumors has become a research hotspot. Tumor-associated macrophages (TAMs) are the most abundant interstitial cells in a tumor's microenvironment. As the concentration of the prepared nanoparticles increased, so their cytotoxicity of intensified. Under photothermal conditions, mAb-CD163/Au inhibited tumor invasion by killing M2 macrophages in vitro. After exposure to near-infrared (NIR) laser, mAb-CD163/Au inhibited tumor growth in vivo. The gold nanoparticles were modified to target M2 macrophages. Under NIR laser irradiation, mAb-CD163/Au achieved antitumor effects by killing M2 macrophages in vitro and in vivo. © 2021. The Author(s), under exclusive licence to Springer-Verlag London Ltd. part of Springer Nature.

Citation

Bo Wang, Ying Huang. Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions. Lasers in medical science. 2022 Feb;37(1):299-307