Energy released from beta emission causes molecules that incorporate tritium (3 H) and carbon-14 (14 C) atoms to be less stable than their stable labeled counterparts, thus making radiolabeled compounds prone to self-radiolysis. This literature review examines the stability of organic compounds incorporating 3 H and 14 C atoms and discusses stability of the compound with respect to functional groups within the radiolabeled molecules. The goal of this paper is to serve as a reference for the stability of radiolabeled compounds. © 2021 John Wiley & Sons, Ltd.
Jeremy R Wolf. Review: Self-radiolysis of compounds containing tritium and carbon-14. Journal of labelled compounds & radiopharmaceuticals. 2021 Jun 30;64(8):286-335
PMID: 33439502
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