Nuclear Receptors and Development of Marine Invertebrates.

Angelica Miglioli, Laura Canesi, Isa D L Gomes, Michael Schubert, Rémi Dumollard

Genes 2021 Jan 11

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Nuclear Receptors (NRs) are a superfamily of transcription factors specific to metazoans that have the unique ability to directly translate the message of a signaling molecule into a transcriptional response. In vertebrates, NRs are pivotal players in countless processes of both embryonic and adult physiology, with embryonic development being one of the most dynamic periods of NR activity. Accumulating evidence suggests that NR signaling is also a major regulator of development in marine invertebrates, although ligands and transactivation dynamics are not necessarily conserved with respect to vertebrates. The explosion of genome sequencing projects and the interpretation of the resulting data in a phylogenetic context allowed significant progress toward an understanding of NR superfamily evolution, both in terms of molecular activities and developmental functions. In this context, marine invertebrates have been crucial for characterizing the ancestral states of NR-ligand interactions, further strengthening the importance of these organisms in the field of evolutionary developmental biology.

Citation

Angelica Miglioli, Laura Canesi, Isa D L Gomes, Michael Schubert, Rémi Dumollard. Nuclear Receptors and Development of Marine Invertebrates. Genes. 2021 Jan 11;12(1)