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Amyloid β-protein (Aβ) oligomers are broadly viewed as the proximate mediators of toxicity in Alzheimer's disease (AD). Recent studies, however, provide substantial evidence that is involved in protection and repair of the central nervous system whereby oligomer and subsequent fibril formation are integral to its normal antimicrobial and antiviral function. These developments raise a question of what exactly makes oligomers toxic in the context of AD. This Perspective describes a paradigm shift in the search for toxic oligomer species that involves oxidative-stress-induced stabilization of oligomers via cross-linking and reviews most recent research elucidating structural aspects of cross-linked oligomers and potential inhibition of their toxicity.


Brigita Urbanc. Cross-Linked Amyloid β-Protein Oligomers: A Missing Link in Alzheimer's Disease Pathology? The journal of physical chemistry. B. 2021 Feb 11;125(5):1307-1316

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PMID: 33440940

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