Acute and subacute (28 days) oral toxicity studies of tucum almond oil (Bactris Setosa Mart.) in mice.
Luane Aparecida do Amaral, Andressa Carolina Farias Pereira Subtil Cavalcante, Tainá da Silva Fleming de Almeida, Mirelly Marques Romeiro Santos, Luciane Candeloro Portugal, Bárbara Suzuki Dos Santos, Felipe Francisco Bittencourt, Thiago Troquez, Carlos Eduardo Domingues Nazário, Leandro Fontoura Cavalheiro, Bruna Paola Murino Rafacho, Antonio Carlos Duenhas Monreal, Rodrigo Juliano Oliveira, Elisvânia Freitas Dos Santos
Drug and chemical toxicology 2022 JulOils extracted from almonds are often used with particular interest due to their prospective health effects and benefits. Tucum is a Pantanal fruit widely consumed by local population and no in vivo toxicity studies regarding its safety are available in the literature to date. This study investigated the acute and subacute toxicity of tucum almond oil (TAO) in mice by evaluating its safety profile. For the acute (2000 mg/kg) and subacute (250, 500 and 1000 mg/kg) toxicity studies, TAO was administered orally to mice according to 425 and 407 Organization for Economic Cooperation and Development Guidelines, respectively. Food intake, body, and organ weight of animals were recorded. Signs of toxicity were assessed, and hematological, biochemical and histopathological analyses were performed. In the acute toxicity study, no mortality or behavioral changes were observed in mice treated with 2000 mg/kg, indicating that LD50 is higher than this dose. In the subacute toxicity test, the doses evaluated did not produce relevant changes in hematological, biochemical or histopathological parameters in the exposed animals. The data obtained suggest that TAO did not induce toxicity after exposure to a single or repeated doses and LD50 value may be considered to be more than 2000 mg/kg body weight.
Citation
Luane Aparecida do Amaral, Andressa Carolina Farias Pereira Subtil Cavalcante, Tainá da Silva Fleming de Almeida, Mirelly Marques Romeiro Santos, Luciane Candeloro Portugal, Bárbara Suzuki Dos Santos, Felipe Francisco Bittencourt, Thiago Troquez, Carlos Eduardo Domingues Nazário, Leandro Fontoura Cavalheiro, Bruna Paola Murino Rafacho, Antonio Carlos Duenhas Monreal, Rodrigo Juliano Oliveira, Elisvânia Freitas Dos Santos. Acute and subacute (28 days) oral toxicity studies of tucum almond oil (Bactris Setosa Mart.) in mice. Drug and chemical toxicology. 2022 Jul;45(4):1754-1760
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PMID: 33441004
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