Bone Marrow Failure Syndromes, Overlapping Diseases with a Common Cytokine Signature.

Valentina Giudice, Chiara Cardamone, Massimo Triggiani, Carmine Selleri

International journal of molecular sciences 2021 Jan 12

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Bone marrow failure (BMF) syndromes are a heterogenous group of non-malignant hematologic diseases characterized by single- or multi-lineage cytopenia(s) with either inherited or acquired pathogenesis. Aberrant T or B cells or innate immune responses are variously involved in the pathophysiology of BMF, and hematological improvement after standard immunosuppressive or anti-complement therapies is the main indirect evidence of the central role of the immune system in BMF development. As part of this immune derangement, pro-inflammatory cytokines play an important role in shaping the immune responses and in sustaining inflammation during marrow failure. In this review, we summarize current knowledge of cytokine signatures in BMF syndromes.

Citation

Valentina Giudice, Chiara Cardamone, Massimo Triggiani, Carmine Selleri. Bone Marrow Failure Syndromes, Overlapping Diseases with a Common Cytokine Signature. International journal of molecular sciences. 2021 Jan 12;22(2)