Junjie Zhu, Ping Xiong, Ziyang Li, Jiazhong Li, Longsheng Lin, Xing Fu, Yuxuan Huang, Yahong Xiong, Chunyuan Li
Natural product research 2022 MarTo search for antifungal leads, the metabolites of an insect-derived fungus Fusarium lateritium ZMT01 were investigated, providing five sesquiterpenes (1-5), including new molecules microsphaeropsisins D and E (1 and 2). The evaluated antifungal activities in vitro which are higher than the positive control triadimefon include: 1 and 2 towards Fusarium oxysporum (MICs 50, 25 mg L-1; triadimefon 100 mg L-1); 1, 2, 4 and 5 towards Penicillium italicum (MICs 25, 12.5, 25, 25; triadimefon 50 mg L-1), 1, 2 and 4 towards Colletotrichum musae (MICs 25, 12.5, 25; triadimefon 80 mg L-1), 2 and 4 towards Fusarium graminearum (MICs 100, 100; triadimefon 150 mg L-1). The bioassay in vivo displayed that the banana anthracnose control effect of 2 (100 mg L-1) was also higher than that of triadimefon (Inhibition ratios 27.5 ± 2.5%, 55.3 ± 1.4%, 52.1 ± 1.3% for 2, 22.5 ± 2.1%, 47.2 ± 2.0%, 36.6 ± 2.2% for triadimefon at 4 d, 8 d and 12 d, respectively).[Formula: see text].
Junjie Zhu, Ping Xiong, Ziyang Li, Jiazhong Li, Longsheng Lin, Xing Fu, Yuxuan Huang, Yahong Xiong, Chunyuan Li. Antifungal sesquiterpenes with post-harvest anthracnose control effect on bananas from the fungus Fusarium lateritium. Natural product research. 2022 Mar;36(5):1245-1252
PMID: 33445960
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