Musculin is highly enriched in Th17 and IL-22-producing ILC3s and restrains pro-inflammatory cytokines in murine colitis.

Jun Yan, Jing Yu, Shunzong Yuan, Wanqi Tang, Wei Ma, Xue Yang, Yijia Liu, Huaping Liang, Xuemei Zhong, Jing Shao, Yang Cao, Changchuin Mao, Richard Near, Wenda Gao

European journal of immunology 2021 Apr

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Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC+/+ mice survived DSS-induced colitis, MSC-/- mice showed elevated pro-inflammatory cytokines with severer pathology, reduced body weight, and earlier death. Reversal of colitis symptoms in MSC-/- mice by IL-22 antagonism suggests the existence of MSC:IL-22 regulatory axis. © 2021 Wiley-VCH GmbH.

Citation

Jun Yan, Jing Yu, Shunzong Yuan, Wanqi Tang, Wei Ma, Xue Yang, Yijia Liu, Huaping Liang, Xuemei Zhong, Jing Shao, Yang Cao, Changchuin Mao, Richard Near, Wenda Gao. Musculin is highly enriched in Th17 and IL-22-producing ILC3s and restrains pro-inflammatory cytokines in murine colitis. European journal of immunology. 2021 Apr;51(4):995-998