Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.

Xujun Song, Benno Traub, Jingwei Shi, Marko Kornmann

International journal of molecular sciences 2021 Jan 13

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Interleukin (IL)-4 and -13 are structurally and functionally related cytokines sharing common receptor subunits. They regulate immune responses and, moreover, are involved in the pathogenesis of a variety of human neoplasms. Three different receptors have been described for IL-4, but only IL-4 receptor type II (IL-4Rα/IL-13Rα1) is expressed in solid tumors. While IL-13 can also bind to three different receptors, IL-13 receptor type I (IL-4Rα/IL-13Rα1/IL-13Rα2) and type II (IL-4Rα/IL-13Rα1) are expressed in solid tumors. After receptor binding, IL-4 and IL-13 can mediate tumor cell proliferation, survival, and metastasis in gastric or colon cancer. This review summarizes the results about the role of IL-4/IL-13 and their receptors in gastric and colon cancer.

Citation

Xujun Song, Benno Traub, Jingwei Shi, Marko Kornmann. Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer. International journal of molecular sciences. 2021 Jan 13;22(2)