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Retinoic acid (RA) induces granulocytic differentiation and inhibits the growth of human promyelocytic leukemia HL60 cells. α-Actinin-4 is a member of the α-actinin family, which exhibits unique mechanosensory regulation. Herein, we elucidated the effects of RA on α-actinin-4 expression during cell differentiation. RA increased the levels of α-actinin-4 protein significantly, while mRNA expression remained unchanged. In addition, RA treatment altered the intracellular localization of α-actinin-4 from the nucleus to the cytoplasm. Cells pretreated with RA, maintained α-actinin-4 protein levels after cycloheximide treatment as compared with control cells. The amount of ubiquitylated α-actinin-4 protein in RA-treated cells was less than in control cells. These results indicate that RA may inhibit nuclei transport and proteasomal degradation of α-actinin-4 protein. α-Actinin-4 may play a significant role in RA-induced differentiation, including the promotion of cytomorphology changes. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.


Daisuke Saito, Masahiko Imai, Chiho Yamada, Noriko Takahashi. Changes in the levels of α-actinin-4 in differentiating human myeloid leukemia cells induced by retinoic acid. Biochimica et biophysica acta. Molecular cell research. 2021 May;1868(6):118968

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PMID: 33454316

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