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For a chemotherapeutic agent to be effective, it must conquer the presence of blood-brain barrier (BBB), which limits the penetration of drugs into the brain. Tumours in the brain compromise the integrity of BBB and result in a highly heterogeneous vasculature, known as blood-brain tumour barrier (BBTB). In this chapter, we firstly highlight the cellular and molecular characteristics of the BBB and BBTB as well as the challenges aroused by BBB/BBTB for drug delivery. Secondly, we discuss the current strategies overcoming the challenges in invasive and non-invasive manners. Finally, we highlight the emerging strategy using focused ultrasound (FUS) with systemic microbubbles to transiently and reversibly enhance the permeability of these barriers for drug delivery. © 2020. Springer Nature Switzerland AG.


Sheng-Kai Wu, Chia-Lin Tsai, Kullervo Hynynen. Novel Treatment Approaches for Brain Tumour from a Blood-Brain Barrier Perspective. Handbook of experimental pharmacology. 2022;273:351-364

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PMID: 33454856

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