Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis.

Chao-Chun Yang, Chin-Han Wu, Tak-Wah Wong, Feng-Jie Lai, Kai-Che Wei, Tzu-Kai Lin, Chrang-Shi Lin, Juemin Zhao, Leihong Xiang, Chao-Hsing Kao, Ying-Jan Wang, Cheng-Che Eric Lan, Hamm-Ming Sheu

The Journal of dermatology 2021 Mar

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SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK. © 2021 Japanese Dermatological Association.

Citation

Chao-Chun Yang, Chin-Han Wu, Tak-Wah Wong, Feng-Jie Lai, Kai-Che Wei, Tzu-Kai Lin, Chrang-Shi Lin, Juemin Zhao, Leihong Xiang, Chao-Hsing Kao, Ying-Jan Wang, Cheng-Che Eric Lan, Hamm-Ming Sheu. Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis. The Journal of dermatology. 2021 Mar;48(3):344-352