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One pair of new amides enantiomers (1a and 1b) and two known amides were isolated from the rhizomes of Polygonum cuspidatum. Their structures were established using UV, IR, HRESIMS, and NMR data. Notably, compound 1 possesses unique C-C connection between feruloyltyramine and resveratrol. Their absolute configurations were determined by the ECD method. All compounds were evaluated for their α-glucosidase inhibitory activity and compounds 2 and 3 showed significant inhibitory activity with IC50 values of 2.82 and 13.06 μmol/L, respectively (positive control acarbose, IC50 385 μmol/L).


Xu Zhang, Fu Liu, Zi-Ming Feng, Jian-Shuang Jiang, Ya-Nan Yang, Pei-Cheng Zhang. Bioactive amides from Polygonum cuspidatum. Journal of Asian natural products research. 2021 Mar;23(3):228-234

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PMID: 33459060

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