Correlation Engine 2.0
Clear Search sequence regions

  • and disease (1)
  • cancer (3)
  • cell cycle (2)
  • chondroitin (2)
  • encyclopedia (1)
  • fibrosarcoma (1)
  • free (3)
  • gene (4)
  • human (3)
  • leiomyosarcoma (1)
  • liposarcoma (1)
  • liposarcoma myxoid (1)
  • prognosis (4)
  • protein human (5)
  • proteoglycans (2)
  • rna (2)
  • sarcoma (11)
  • SMC1A (4)
  • SMC2 (5)
  • SMC3 (3)
  • smc3 protein, human (1)
  • SMC4 (4)
  • SMC5 (4)
  • SMC6 (4)
  • Sizes of these terms reflect their relevance to your search.

    To explore the prognostic value of the expression of genes encoding structural maintenance of chromosomes (SMCs) in human sarcoma. We found that the levels of SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 mRNA were all higher in most tumors compared to normal tissues, and especially in sarcoma. According to the Cancer Cell Line Encyclopedia (CCLE), SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 are also highly expressed in sarcoma cell lines. Results of Gene Expression Profiling Interactive Analysis (GEPIA) indicated that high expression of SMC1A was significantly related to poor overall survival (OS) (p<0.05) and disease-free survival (DFS) in sarcoma (p<0.05). Additionally, strong expression of SMC2 was significantly related to poor OS in sarcoma (p<0.05). In contrast, SMC3, SMC4, SMC5, and SMC6 expression had no significant impact on OS or DFS in sarcoma. Expression of SMC family members is significantly different in sarcoma relative to normal tissues, and SMC1A and SMC2 may be useful as prognostic biomarkers. We performed a detailed comparison of cancer and normal tissues regarding the expression levels of mRNA for SMC family members in various cancers including sarcoma through ONCOMINE and GEPIA (Gene Expression Profile Interactive Analysis) databases.


    Jian Zhou, Gen Wu, Zhongyi Tong, Jingjing Sun, Jing Su, Ziqin Cao, Yingquan Luo, Wanchun Wang. Prognostic relevance of SMC family gene expression in human sarcoma. Aging. 2020 Dec 30;13(1):1473-1487

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33460400

    View Full Text