ZnCuInSe/Au/TiO2 sandwich nanowires-based photoelectrochemical biosensor for ultrasensitive detection of kanamycin.

Hongchao Geng, Xiaoxu Chen, Leilei Sun, Yan Qiao, Jie Song, Sisi Shi, Qingyun Cai

Analytica chimica acta 2021 Feb 15

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A highly selective and sensitive photoelectrochemical (PEC) sensing platform was developed for kanamycin assay based on the aptamer modified sandwich-structured ZnCuInSe/Au/TiO2 nanowires. Sandwiched between the TiO2 nanowires and the ZnCuInSe quantum dot (QDs) layer, the Au nanoparticles (Au NPs) serves as a plasmonic photosensitizer and an electron relay, which expand the light absorption range and facilitates the charge transfer. Also, ZnCuInSe QDs, a broad spectrum photosensitizer can capture visible light, which enhance the photocurrent density response. Through the Au-S bond and Cu-S bond, the HS-aptamer were immobilized on the ZnCuInSe/Au/TiO2 nanowires as a recognition unit for kanamycin. The proposed sensing platform showed excellent assay performance for kanamycin with a linear response range from 0.2 to 250 nM, and high selectivity. By changing the recognizers, the proposed sensing platform could be easily extended to detect other biomolecules, and may have a promising application in bioanalysis. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Hongchao Geng, Xiaoxu Chen, Leilei Sun, Yan Qiao, Jie Song, Sisi Shi, Qingyun Cai. ZnCuInSe/Au/TiO2 sandwich nanowires-based photoelectrochemical biosensor for ultrasensitive detection of kanamycin. Analytica chimica acta. 2021 Feb 15;1146:166-173