The ladderane family of natural products are well known for their linearly concatenated cyclobutane skeletal structure. Owing to their unique carbocyclic framework, several chemical syntheses have been reported since their discovery in 2002. The focus of this review is to showcase the novel tactics that have been used to generate the ladderane core and the challenges that are associated with the synthesis of these unusual and complex natural products. © 2020 Wiley‐VCH GmbH.
Erin N Hancock, M Kevin Brown. Ladderane Natural Products: From the Ground Up. Chemistry (Weinheim an der Bergstrasse, Germany). 2021 Jan 07;27(2):565-576
PMID: 33463810
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