In Vitro Resistance and Evolution of Resistance to Tavaborole in Trichophyton rubrum.

Diletta Mazzantini, Francesco Celandroni, Marco Calvigioni, Antonella Lupetti, Emilia Ghelardi

Antimicrobial agents and chemotherapy 2021 Mar 18

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Tavaborole is currently used in the topical treatment of onychomycosis. In this study, we analyzed the in vitro emergence/evolution of resistance against tavaborole in Trichophyton rubrum When T. rubrum strains were propagated on media containing the MIC of tavaborole, spontaneous resistant mutants were isolated at a frequency of 10-8 The frequency was almost 100-fold higher following fungal growth in the presence of a subinhibitory tavaborole concentration (0.5-fold the MIC) for 10 transfers. All collected mutants showed similar 4- to 8-fold increases in the drug MIC. No cross-resistance to other antifungals was evident. Copyright © 2021 American Society for Microbiology.

Citation

Diletta Mazzantini, Francesco Celandroni, Marco Calvigioni, Antonella Lupetti, Emilia Ghelardi. In Vitro Resistance and Evolution of Resistance to Tavaborole in Trichophyton rubrum. Antimicrobial agents and chemotherapy. 2021 Mar 18;65(4)