Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii.

Jiaqi Cheng, Jun Yan, Zeferino Reyna, Matt Slarve, Peggy Lu, Brad Spellberg, Brian Luna

Antimicrobial agents and chemotherapy 2021 Mar 18

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Recently, we reported rifabutin hyperactivity against Acinetobacter baumannii We sought to characterize potential interactions between rifabutin and colistin, the last-resort drug for carbapenem-resistant infections. Rifabutin and colistin were synergistic in vitro and in vivo, and low-dose colistin significantly suppressed emergence of resistance to rifabutin. Thus, this combination is a promising therapeutic option for highly resistant A. baumannii infections. Copyright © 2021 Cheng et al.

Citation

Jiaqi Cheng, Jun Yan, Zeferino Reyna, Matt Slarve, Peggy Lu, Brad Spellberg, Brian Luna. Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii. Antimicrobial agents and chemotherapy. 2021 Mar 18;65(4)