o-Quinone Methides and o-Quinone Sulfides via Arynes: Synthesis of Ortho-Disubstituted Arenes and Heterocycles.

In recent decades, o-quinone methides and o-quinone sulfides have been extensively highlighted as reactive intermediates for the synthesis of diversely functionalized ortho-disubstituted arenes and heterocycles. Additionally, ortho-disubstituted arenes offer a constructive path for the synthesis of fused carbocycles, heterocycles, natural products, and drug candidates. In the lieu of that, this Synopsis highlights a comprehensive overview on the potential applications of in situ generated o-quinone methides and o-quinone sulfides for one-pot synthesis of ortho-disubstituted arenes and heterocycles via arynes.

Citation

Abhilash Sharma, Hemanta Hazarika, Pranjal Gogoi. o-Quinone Methides and o-Quinone Sulfides via Arynes: Synthesis of Ortho-Disubstituted Arenes and Heterocycles. The Journal of organic chemistry. 2021 Apr 02;86(7):4883-4895

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PMID: 33471525

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