Physical evidence on desmin-lamin B interaction.

Desmin is a muscle specific intermediate filament protein located in cytoplasm. Lamin B, on the other hand, is a nuclear intermediate filament protein. There are studies suggesting a possible interaction between desmin and lamin B yet there is no physical evidence. In the present study, we have shown for the first time a physical interaction between desmin and lamin B via reciprocal co-immunoprecipitation from muscle tissue of wild type AB zebrafish (Danio rerio, Hamilton). The interaction between desmin and lamin B might be a lead on a novel nucleocytoplasmic communication network. © 2021 Wiley Periodicals LLC.

Citation

Ecem Kural-Mangıt, Pervin Rukiye Dinçer. Physical evidence on desmin-lamin B interaction. Cytoskeleton (Hoboken, N.J.). 2021 Jan;78(1):14-17

PMID: 33475247

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