Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.

Hui Feng, Yi-Bing Zhang, Jian-Fang Gui, Stanley M Lemon, Daisuke Yamane

PLoS pathogens 2021 Jan

filter terms:

The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader view, linking IRF1 to a wide range of functions in protection against invading pathogens. Conserved throughout vertebrate evolution, IRF1 has been shown in recent years to mediate constitutive as well as inducible host defenses against a variety of viruses. Fine-tuning of these ancient IRF1-mediated host defenses, and countering strategies by pathogens to disarm IRF1, play crucial roles in pathogenesis and determining the outcome of infection.

Citation

Hui Feng, Yi-Bing Zhang, Jian-Fang Gui, Stanley M Lemon, Daisuke Yamane. Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses. PLoS pathogens. 2021 Jan;17(1):e1009220