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TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation properties that pave a path toward new avenues in the treatment of chronic pain. Copyright © 2020 Elsevier Inc. All rights reserved.


Michael Fine, Xiaochun Li. Insights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM. Neuron. 2021 Jan 20;109(2):194-196

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PMID: 33476560

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