Bookmark
Forward
Insights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM.
Neuron 2021 Jan 20Sizes of these terms reflect their relevance to your search.
TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation properties that pave a path toward new avenues in the treatment of chronic pain. Copyright © 2020 Elsevier Inc. All rights reserved.
Citation
Michael Fine, Xiaochun Li. Insights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM. Neuron. 2021 Jan 20;109(2):194-196
Mesh Tags
Substances
PMID: 33476560
View Full Text
