TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism.

Stephanie Graser, Daniel Liedtke, Franz Jakob

International journal of molecular sciences 2021 Jan 18

filter terms:

This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding ALPL gene. We emphasize the role of TNAP beyond its well-known contribution to mineralization processes. Therefore, above all, the impact of the enzyme on central molecular processes in the nervous system and on inflammation is presented here.

Citation

Stephanie Graser, Daniel Liedtke, Franz Jakob. TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism. International journal of molecular sciences. 2021 Jan 18;22(2)