Immunohistochemical Analysis of Programmed Death-Ligand 1 Expression in Equine Sarcoids.

Jennifer Benvegnen, Bettina De Breuyn, Vinzenz Gerber, Sven Rottenberg, Christoph Koch

Journal of equine veterinary science 2021 Feb

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The aim of the study was to assess the expression of the immune checkpoint inhibitor programmed death-ligand 1 (PD-L1) in equine sarcoids (ES). Programmed death-ligand 1 is expressed by various cancer cells to block T cell-mediated elimination of tumor cells. Antibodies targeting human PD-L1 were tested by immunohistochemistry for their cross-reactivity with equine PD-L1 using formalin-fixed, paraffin-embedded tissues. Our results do not support an important role of PD-L1-mediated immune evasion in ES disease and hence do not offer a rationale for anti-PD-1/PD-L1-based immunotherapy against ES. Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Jennifer Benvegnen, Bettina De Breuyn, Vinzenz Gerber, Sven Rottenberg, Christoph Koch. Immunohistochemical Analysis of Programmed Death-Ligand 1 Expression in Equine Sarcoids. Journal of equine veterinary science. 2021 Feb;97:103338