Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

To evaluate the frequency of alpha thalassemia and detect mutations in the alpha genes in individuals undergoing premarital screening. The cross-sectional study was conducted at King Fahad Central Hospital, Jazan, Saudi Arabia, from January 2018 to May 2019, and comprised blood samples of individuals visiting the premarital screening clinic. The samples were analyzed for complete blood counts and haemoglobin electrophoresis. Molecular analysis of samples suspected for alpha thalassemia was done using alpha-globin StripAssay kit. Data was anlaysed using SPSS 20. Of the 3,970 samples analysed, 1,859(46.83%) were from males and 2,111(53.17%) from females. The overall frequency of suspected alpha thalassemia was 4.43% based upon haematological parameters including complete blood count and haemoglobin electrophoresis. Overall, 80 suspected samples were selected for genetic analyses, and, of them, 76 (95%) were positive for deletional and non-deletional mutations of alpha-globin genes, while 4 (5%) were negative for any of the 21 mutations tested. Alpha thalassemia was found to be highly prevalent in the study area.


Muhammad Saboor, Abdullah Ahmed Mobarki, Hassan Abdu Hamali, Amr Jamal Halawani, Saleh Mohammed Abdullah, Ayman Mohsen Mashi, Yahya Hassan Hobani. Frequency and genotyping of alpha thalassemia in individuals undergoing premarital screening. JPMA. The Journal of the Pakistan Medical Association. 2021 Jan;71(1(A)):101-104

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 33484530

View Full Text