Mutant Mice and Animal Models of Airway Allergic Disease.

Julyanne Brassard, David Marsolais, Marie-Renee Blanchet

Methods in molecular biology (Clifton, N.J.) 2021

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Eosinophilia is a hallmark of allergic airway inflammation, and eosinophils represent an integral effector leukocyte through their release of various granule-stored cytokines and proteins. Numerous mouse models have been developed to mimic clinical disease and they have been instrumental in furthering our understanding of the role of eosinophils in disease. Most of these models consist of intranasal (i.n.) administration of antigenic proteases including papain and house dust mite (HDM) or the neo-antigen ovalbumin, with a resulting Th2-biased immune response and airway eosinophilia. These models have been particularly informative when combined with the numerous transgenic mice available that modulate eosinophil frequency or the mechanisms involved in their migration. Here, we describe the current models of allergic airway inflammation and outline some of the transgenic mice available to study eosinophil disease.

Citation

Julyanne Brassard, David Marsolais, Marie-Renee Blanchet. Mutant Mice and Animal Models of Airway Allergic Disease. Methods in molecular biology (Clifton, N.J.). 2021;2241:59-74