Role of Munc18-1 in the biological functions and pathogenesis of neurological disorders (Review).

Fajuan Tang, Dongqiong Xiao, Lin Chen, Hu Gao, Xihong Li

Molecular medicine reports 2021 Mar

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The release of neurotransmitters following the fusion of synaptic vesicles and the presynaptic membrane is an important process in the transmission of neuronal information. Syntaxin-binding protein 1 (Munc18-1) is a synaptic fusion protein binding protein, which mainly regulates synaptic vesicle fusion and neurotransmitter release by interacting with soluble N-ethylmaleimide sensitive factor attachment protein receptor. In addition to affecting neurotransmitter transmission, Munc18-1 is also involved in regulating neurosynaptic plasticity, neurodevelopment and neuroendocrine cell release functions (including thyroxine and insulin release). A number of previous studies have demonstrated that Munc18-1 has diverse and vital biological functions, and that its abnormal expression serves an important role in the pathogenesis of a variety of neurological diseases, including epileptic encephalopathy, schizophrenia, autism, Parkinson's disease, Alzheimer's disease, multiple sclerosis, Duchenne's muscular dystrophy and neuronal ceroid lipofuscinosis. The present review summarizes the function of Munc18-1 and its possible relationship to the pathogenesis of various neurological diseases.

Citation

Fajuan Tang, Dongqiong Xiao, Lin Chen, Hu Gao, Xihong Li. Role of Munc18-1 in the biological functions and pathogenesis of neurological disorders (Review). Molecular medicine reports. 2021 Mar;23(3)