Acute kidney injury secondary to severe delayed haemolysis in intravenous artesunate use for severe malaria.

Kai Wen Leong, Kasha P Singh, Karin Leder, Steven Y C Tong

BMJ case reports 2021 Jan 26

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The use of artemisinin derivatives has been recommended by the WHO guidelines in malaria treatment largely due to its rapid parasite clearance and safety profile. This case report details the development of delayed haemolysis and subsequent severe acute kidney injury (AKI) 13 days after commencing intravenous artesunate treatment for malaria in an Australian returned traveller. Delayed haemolysis may be an under-recognised complication following artesunate use and if severe, can be complicated by AKI. Therefore, close patient follow-up following treatment is required to ensure prompt recognition of this phenomenon. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Citation

Kai Wen Leong, Kasha P Singh, Karin Leder, Steven Y C Tong. Acute kidney injury secondary to severe delayed haemolysis in intravenous artesunate use for severe malaria. BMJ case reports. 2021 Jan 26;14(1)