Visible-light promoted α-alkylation of glycine derivatives with alkyl boronic acids.

A visible-light-mediated aerobic α-alkylation reaction of glycine derivatives with alkyl boronic acids has been established in the presence of a Ru/Cu catalyst system, giving the desired radical coupling products efficiently. The transformation features mild reaction conditions and broad substrate scope, delivering a wide range of complex unnatural α-amino-acid derivatives.

Citation

Jiayuan Wang, Yingpeng Su, Zhengjun Quan, Jun Li, Jie Yang, Yong Yuan, Congde Huo. Visible-light promoted α-alkylation of glycine derivatives with alkyl boronic acids. Chemical communications (Cambridge, England). 2021 Feb 23;57(15):1959-1962

PMID: 33502406

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