Treatment Patterns With Antipsychotics in Long-Term Care Patients With Parkinson's Disease Psychosis.

Nazia Rashid, Andrew Shim, Sherry Andes, Sonja Quale, Victor Abler

Journal of applied gerontology : the official journal of the Southern Gerontological Society 2022 Jan

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This study assessed treatment change patterns in Parkinson's disease psychosis (PDP) residents receiving antipsychotic (AP) therapies in U.S. long-term care (LTC) facilities. Residents with PDP in LTC between 01/01/13 and 06/30/16 were identified with ≥1 claim of psychosis, hallucinations, or delusions after PD diagnosis. Treatment patterns were evaluated during the 12 months post index. We identified 864 PDP residents: 408 (47.2%) on AP therapy and 456 (52.8%) on no AP therapy. A total of 335 residents (82.1%) continued, 13 (3.2%) discontinued, 11 (2.7%) switched, and 49 (12.0%) augmented (used ≥2 APs) their index AP therapy. Based on the multivariate regression analysis, younger age, male gender, anemia, anxiolytic use or anxiety, sedatives/hypnotic use, bladder disorders including urinary tract infections, coronary conditions, diabetes, hypertension, and dementia were associated with a higher likelihood of treatment change. Understanding the factors associated with treatment change may inform ways to improve management of PDP in the U.S. LTC setting.

Citation

Nazia Rashid, Andrew Shim, Sherry Andes, Sonja Quale, Victor Abler. Treatment Patterns With Antipsychotics in Long-Term Care Patients With Parkinson's Disease Psychosis. Journal of applied gerontology : the official journal of the Southern Gerontological Society. 2022 Jan;41(1):198-206