Minor triterpenes from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla.

Ruo-Fei Li, Qing-Lan Guo, Cheng-Gen Zhu, Cheng-Bo Xu, Ya-Zi Wei, Jian Cai, Yue Wang, Hua Sun, Tian-Tai Zhang, Jian-Gong Shi

Journal of Asian natural products research 2021 Apr

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Six new triterpenes, uncarinic acids KP (1-6), along with 24 known analogues, were isolated as minor constituents of an aqueous decoction of the hook-bearing stems of Uncaria rhynchophylla (Gou-teng). By comprehensive spectroscopic data analysis, their structures were elucidated as derivatives of olean-12-en-28-oic acid and urs-12-en-28-oic acid with different oxidized forms at C-3, C-6, and/or C-23, respectively. Cell-based preliminary bioassay showed that the (E)-/(Z)-coumaroyloxy and (E)-/(Z)-feruloyloxy units at C-27 of olean-12-en-28-oic acid and urs-12-en-28-oic acid played roles in their bioactivities.[Formula: see text].

Citation

Ruo-Fei Li, Qing-Lan Guo, Cheng-Gen Zhu, Cheng-Bo Xu, Ya-Zi Wei, Jian Cai, Yue Wang, Hua Sun, Tian-Tai Zhang, Jian-Gong Shi. Minor triterpenes from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla. Journal of Asian natural products research. 2021 Apr;23(4):307-317