Coordination-Driven Enhancement of Radiosensitization by Black Phosphorus via Regulating Tumor Metabolism.

Leung Chan, Xiaodan Chen, Pan Gao, Jun Xie, Zhongyang Zhang, Jianfu Zhao, Tianfeng Chen

ACS nano 2021 Feb 23

filter terms:

Coordination-driven surface modification is an effective strategy to achieve nanosystem functionalization and improved physicochemical performance. Black phosphorus (BP)-based nanomaterials demonstrate great potential in cancer therapy, but their poor stability, low X-ray mass attenuation coefficient, and nonselectivity limit the application in radiotherapy. Herein, we used unsaturated iridium complex to coordinate with BP nanosheets to synthesize a two-dimensional layered nanosystem (RGD-Ir@BP) with higher biostability. Ir complex improves the photoelectric properties and photoinduced charge carrier dynamics of BP, hence Ir@BP generated more singlet oxygen after X-ray irradiation. In in vivo experiments, with X-ray irradiation, RGD-Ir@BP effectively inhibited nasopharyngeal carcinoma tumor growth but with minor side effects. Additionally, based on untargeted metabolomics analysis, the combined treatment specifically down-regulated the tumor proliferative mark of prostaglandin E2 in cancer cells. In general, this study provides a design strategy of high-performance coordination-driven BP-based nanosensitizer in cancer radiotherapy.

Citation

Leung Chan, Xiaodan Chen, Pan Gao, Jun Xie, Zhongyang Zhang, Jianfu Zhao, Tianfeng Chen. Coordination-Driven Enhancement of Radiosensitization by Black Phosphorus via Regulating Tumor Metabolism. ACS nano. 2021 Feb 23;15(2):3047-3060