Correlation Engine 2.0
Clear Search sequence regions


  • ACE2 (8)
  • across (40)
  • AD 2 (4)
  • AD 3 (4)
  • AD 4 (4)
  • adenocarcinoma (19)
  • allergen (1)
  • antigens (2)
  • appear (2)
  • bocavirus (2)
  • burkholderia pseudomallei (2)
  • cancer (61)
  • cardiovascular disease (1)
  • cases (9)
  • CD274 (5)
  • cells b (2)
  • cellular (4)
  • chronic lung disease (1)
  • cohort (2)
  • colon (1)
  • control group (5)
  • coronavirus (7)
  • CXCL1 (2)
  • cytokines (4)
  • diseases and (1)
  • distress (1)
  • dust (2)
  • epithelium (2)
  • express genes (2)
  • factors (3)
  • gene (49)
  • gene order (6)
  • gene overlaps (2)
  • genes cancer (1)
  • genes expressed (1)
  • growth factor receptor (1)
  • heat (12)
  • help (2)
  • host cell (4)
  • host responses (17)
  • human (39)
  • human cells (4)
  • human enteroviruses (1)
  • hypoxia (1)
  • IFNB (2)
  • IFNGR1 (1)
  • IFNGR2 (1)
  • il 6 receptor (1)
  • IL1A (1)
  • IL1B (1)
  • illnesses (2)
  • influenza (1)
  • inhibit (1)
  • interferons (4)
  • interleukin- 6 (1)
  • interleukin- 6 (8)
  • KEAP1 (1)
  • lung (24)
  • lung adenocarcinoma (10)
  • lung cancer (2)
  • lung squamous cell carcinoma (2)
  • lung tumors (7)
  • meta analysis (1)
  • metapneumovirus (2)
  • metric (3)
  • mice (6)
  • mild symptoms (1)
  • mite (2)
  • mortality (1)
  • NFKB1 (9)
  • NFKB2 (1)
  • nk cells (2)
  • non- small cell lung cancer (11)
  • normal human bronchial epithelial cells (29)
  • NRF2 (1)
  • p 11 (1)
  • parainfluenza (3)
  • parallels (2)
  • patients (30)
  • PDL2 (4)
  • profiles (23)
  • public domain (1)
  • reads (3)
  • receptor (3)
  • RELB (1)
  • responds (3)
  • responses viruses (6)
  • sars viruses (155)
  • sars- cov- infects (1)
  • squamous cell carcinoma (1)
  • stromal cells (1)
  • suggest (3)
  • systems data (2)
  • systems diseases (1)
  • t cells (2)
  • TNFRSF14 (1)
  • TNFSF14 (1)
  • tocilizumab (1)
  • toxoplasma gondii (2)
  • trachea (5)
  • type i interferons (2)
  • type ii interferon (6)
  • viral gene (1)
  • viral load (7)
  • viral pneumonia (1)
  • viruses influenza (3)
  • Sizes of these terms reflect their relevance to your search.

    A deeper understanding of the molecular biology of SARS-CoV-2 infection, including the host response to the virus, is urgently needed. Commonalities exist between the host immune response to viral infections and cancer. Here, we defined transcriptional signatures of SARS-CoV-2 infection involving hundreds of genes common across lung adenocarcinoma cell lines (A549, Calu-3) and normal human bronchial epithelial cells (NHBE), with additional signatures being specific to one or both adenocarcinoma lines. Cross-examining eight transcriptomic databases, we found that host transcriptional responses of lung adenocarcinoma cells to SARS-CoV-2 infection shared broad similarities with host responses to multiple viruses across different model systems and patient samples. Furthermore, these SARS-CoV-2 transcriptional signatures were manifested within specific subsets of human cancer, involving ~ 20% of cases across a wide range of histopathological types. These cancer subsets show immune cell infiltration and inflammation and involve pathways linked to the SARS-CoV-2 response, such as immune checkpoint, IL-6, type II interferon signaling, and NF-κB. The cell line data represented immune responses activated specifically within the cancer cells of the tumor. Common genes and pathways implicated as part of the viral host response point to therapeutic strategies that may apply to both SARS-CoV-2 and cancer.

    Citation

    Fengju Chen, Yiqun Zhang, Richard Sucgang, Sasirekha Ramani, David Corry, Farrah Kheradmand, Chad J Creighton. Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors. Scientific reports. 2021 Jan 28;11(1):2459

    Expand section icon Mesh Tags


    PMID: 33510359

    View Full Text