Chemical Constituents of the Bulbs of Scilla peruviana and Their Pancreatic Lipase Inhibitory Activity.

Yukiko Matsuo, Asuka Yamashiro, Kanae Ootomo, Mika Nakagawa, Hiroko Tsuchihashi, Niro Inaba, Yoshihiro Mimaki

International journal of molecular sciences 2021 Jan 27

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Scilla species are used as medicinal plants and contain lanosterol-type triterpene glycosides. The phytochemical investigation of the bulbs of Scilla peruviana led to the isolation of 17 compounds, including three new rearranged pentacyclic-lanosterol glycosides (1-3) and two new homoisoflavanone glycosides (12 and 13). The structures of the undescribed compounds were determined by extensive spectroscopic analyses, including two-dimensional (2D) NMR. Among the triterpene glycosides, 2, 3, and 6 showed significant pancreatic lipase inhibitory activity in a concentration-dependent manner in vitro. The oral administration of scillascilloside D-2 (6) reduced serum triglyceride levels in a dose-dependent manner in soybean oil-loaded mice.

Citation

Yukiko Matsuo, Asuka Yamashiro, Kanae Ootomo, Mika Nakagawa, Hiroko Tsuchihashi, Niro Inaba, Yoshihiro Mimaki. Chemical Constituents of the Bulbs of Scilla peruviana and Their Pancreatic Lipase Inhibitory Activity. International journal of molecular sciences. 2021 Jan 27;22(3)