Correlation Engine 2.0
Clear Search sequence regions

  • acers (1)
  • acid (2)
  • ammonia (4)
  • apoptosis (1)
  • bupleurum (3)
  • chickens (1)
  • diet (2)
  • health status (1)
  • ileum (5)
  • saikosaponin d (6)
  • saikosaponin d (1)
  • saponins (2)
  • Sizes of these terms reflect their relevance to your search.

    Ammonia (NH3) at a high concentration has been recognized as a highly poisonous pollutant affecting both air and water quality. NH3, as a stimulus, exerts negative impact on broiler growth and production, but the molecular mechanisms are not clear yet. This study was designed to evaluate the effects of dietary supplementation of Bupleurum falcatum L saikosaponins (SP) on the growth and ileum health status in broilers exposed to NH3. Day-old Arbor Acers broilers (n = 480) were randomly allocated into 1 of 4 treatments. The main factors were dietary SP supplementation (0 or 80 mg/kg of diet) and NH3 challenge (with or without 70 ± 5 ppm NH3). The data of growth, intestinal morphology, and mRNA expression related to ileal function were collected from broilers exposed to NH3 for 7 d. Results showed that NH3 remarkably suppressed growth performance and intestinal development as well as induced biological injuries in the ileum of broilers, resulting from oxidative stress, mucous barrier damage, and immune dysfunction as well as upregulated apoptosis. These negative effects of NH3 were alleviated by the SP supplement. In conclusion, dietary supplementation of SP may be helpful in alleviating the detrimental effects of NH3 on the ileum development in broilers. Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.


    Gang Shu, Dan Xu, Chonglin Ran, Lizi Yin, Juchun Lin, Hualin Fu, Wei Zhang, Shiping Bai, Xi Peng, Xiaoling Zhao, Felix Kwame Amevor. Protective effect of dietary supplementation of Bupleurum falcatum L saikosaponins on ammonia exposure-induced ileum injury in broilers. Poultry science. 2021 Mar;100(3):100803

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33516464

    View Full Text