Prognostic Reappraisal of Postoperative Carcinoembryonic Antigen in T1-2N0 Colorectal Cancer.

Guangzhe Pian, Jun Sang Shin, Sunseok Yoon, Seung Yeop Oh

Anticancer research 2021 Feb

filter terms:

The purpose of this study was to compare the prognostic value of preoperative carcinoembryonic antigen (CEA), preoperative CEA/tumor size and postoperative CEA in stage I colorectal cancer. We analyzed a total of 305 consecutive stage I colorectal cancer patients who underwent a radical surgery at our Department. The patients were divided into low and high preoperative CEA groups, low and high preoperative CEA/tumor size groups, and low and high postoperative CEA groups according to the optimal cut-off values. Multivariate analysis showed that postoperative CEA was independently associated with OS and DFS. However, the preoperative CEA and preoperative CEA/tumor size were not. The prognostic value of postoperative CEA is better than preoperative CEA and preoperative CEA/tumor size in patients with stage I colorectal cancer. Moreover, the common 5 ng/ml cut-off was not optimal for risk stratification in stage I colorectal cancer. Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Citation

Guangzhe Pian, Jun Sang Shin, Sunseok Yoon, Seung Yeop Oh. Prognostic Reappraisal of Postoperative Carcinoembryonic Antigen in T1-2N0 Colorectal Cancer. Anticancer research. 2021 Feb;41(2):1101-1110