Synthesis of polyethylene glycol functional bonded silica gel for selective recognition and separation of α-cyclodextrin.

In this work, we for the first time synthesized the polyethylene glycol (PEG) bonded silica gel via KH-560 as a silane coupling reagent for column chromatography by a solid/liquid surface continuous reaction method. The molecular interaction, structure, morphology, and thermostability was characterized by fourier transform infrared spectroscopy (FTIR), elemental analysis (EA), scanning electronic microscope (SEM) and thermogravimetric analysis (TGA). Given that PEG is capable to self-assemble with α-CD, the PEG bonded silica gel was used as packing of column chromatography to achieve the selective separation of α-cyclodextrin (α-CD) at room temperature and atmospheric pressure. The bonded silica gel column could realize the effective separation of α-CD in the enzymatic hydrolysis mixture, which provides support for industrial separation of α-CD. Copyright © 2021. Published by Elsevier B.V.

Citation

Xinying Zheng, Yang Qin, Xiaobing Meng, Zhengyu Jin, Liuping Fan, Jinpeng Wang. Synthesis of polyethylene glycol functional bonded silica gel for selective recognition and separation of α-cyclodextrin. Journal of chromatography. A. 2021 Feb 22;1639:461917

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PMID: 33524932

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