3D printing-assisted fabrication of a patient-specific antibacterial radial head prosthesis with high periprosthetic bone preservation.

Mohammad Reza Maydanshahi, Ara Nazarian, Denise Eygendaal, Mohammad Hossein Ebrahimzadeh, Amir Reza Kachooei, Seyed Ali Mousavi Shaegh

Biomedical materials (Bristol, England) 2021 Mar 05

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We present a novel fabrication and surgical approach for anatomical reconstruction of a fractured radial head using a patient-specific radial head prosthesis (RHP) made of polymethylmethacrylate (PMMA) bone cement. To this end, the use of PMMA bone cement for prosthesis fabrication was initially investigated using computational modeling and experimental methods. The RHP was fabricated through casting of PMMA bone cement in a silicone mold in the operating room before implantation. To enhance the precision of bony preparation for replacement of the radial head, a patient-specific surgical guide for accurate resection of the radial neck with the desired length was developed. Post-surgical clinical examinations revealed biomechanical restoration of elbow function, owing to the use of the patient-specific RHP and surgical guide. Importantly, follow-up radiographs after a mean follow-up of 18 months revealed bone preservation at the bone-prosthesis interface without any signs of erosion of the capitellum. Taken together, our method demonstrated the safety and efficacy of the PMMA RHP in restoring elbow biomechanics. This also provides a very safe and cost-effective method for making various patient-specific prostheses with localized antibacterial delivery and close mechanical properties to native bone for improved periprosthetic bone regeneration. The clinical trial of this study was registered at Mashhad University of Medical Sciences under the trial registration number 970493. © 2021 IOP Publishing Ltd.

Citation

Mohammad Reza Maydanshahi, Ara Nazarian, Denise Eygendaal, Mohammad Hossein Ebrahimzadeh, Amir Reza Kachooei, Seyed Ali Mousavi Shaegh. 3D printing-assisted fabrication of a patient-specific antibacterial radial head prosthesis with high periprosthetic bone preservation. Biomedical materials (Bristol, England). 2021 Mar 05;16(3)