Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

The dichloromethane extract from leaves of Melicope barbigera (Rutaceae), endemic to the Hawaiian island of Kaua'i, yielded four new and three previously known acetophenones and 2H-chromenes, all found for the first time in M. barbigera. The structures of the new compounds obtained from the dichloromethane extract after purification by chromatographic methods were unambiguously elucidated by spectroscopic analyses including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration was determined by modified Mosher's method. Compounds 2, 4 and the mixture of 6 and 7 exhibited moderate cytotoxic activities against the human ovarian cancer cell line A2780 with IC50 values of 30.0 and 75.7 ┬ÁM for 2 and 4, respectively, in a nuclear shrinkage cytotoxicity assay.


Kim-Thao Le, Jan J Bandolik, Matthias U Kassack, Kenneth R Wood, Claudia Paetzold, Marc S Appelhans, Claus M Passreiter. New Acetophenones and Chromenes from the Leaves of Melicope barbigera A. Gray. Molecules (Basel, Switzerland). 2021 Jan 28;26(3)

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 33525713

View Full Text