Learning from the worm: the effectiveness of protein-bound Moco to treat Moco deficiency.

Aileen K Sewell, Min Han

Genes & development 2021 Feb 01

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Molybdenum cofactor (Moco) is synthesized endogenously in humans and is essential for human development. Supplementation of Moco or its precursors has been explored as a therapy to treat Moco-deficient patients but with significant limitations. By using the nematode C. elegans as a model, Warnhoff and colleagues (pp. 212-217) describe the beneficial impact of protein-bound Moco supplementation to treat Moco deficiency. If such an effect is conserved, this advance from basic research in worms may have significant clinical implications as a novel therapy for molybdenum cofactor deficiency. © 2021 Sewell and Han; Published by Cold Spring Harbor Laboratory Press.

Citation

Aileen K Sewell, Min Han. Learning from the worm: the effectiveness of protein-bound Moco to treat Moco deficiency. Genes & development. 2021 Feb 01;35(3-4):177-179