Systematic analysis using a bioinformatics strategy identifies SFTA1P and LINC00519 as potential prognostic biomarkers for lung squamous cell carcinoma.

Lung cancer has high incidence and mortality rates, in which lung squamous cell carcinoma (LUSC) is a primary type of non-small cell lung carcinoma (NSCLC). The aim of our study was to discover long non-coding RNAs (lncRNAs) associated with diagnose and prognosis for LUSC. RNA sequencing data obtained from LUSC samples were extracted from The Cancer Genome Atlas database (TCGA). Two prognosis-associated lncRNAs (including SFTA1P and LINC00519) were selected from LUSC samples, and the expression levels were also verified to be associated abnormal in LUSC clinical samples. Our findings demonstrate that lncRNAs SFTA1P and LINC00519 exert important functions in human LUSC and may serve as new targets for LUSC diagnosis and therapy. AJTR Copyright © 2021.

Citation

Yu-Zhen Yin, Shi-Hua Yao, Chun-Guang Li, Yu-Shui Ma, Zhou-Jun Kang, Jia-Jia Zhang, Cheng-You Jia, Li-Kun Hou, Shan-Shan Qin, Xin Fan, Han Zhang, Meng-Die Yang, Dan-Dan Zhang, Gai-Xia Lu, Hui-Min Wang, Li-Peng Gu, Lin-Lin Tian, Pei-Yao Wang, Ping-Sheng Cao, Wei Wu, Zi-Yang Cao, Zhong-Wei Lv, Bo-Wen Shi, Chun-Yan Wu, Geng-Xi Jiang, Da Fu, Fei Yu. Systematic analysis using a bioinformatics strategy identifies SFTA1P and LINC00519 as potential prognostic biomarkers for lung squamous cell carcinoma. American journal of translational research. 2021;13(1):168-182

PMID: 33527016

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