The multifaceted roles of DNA repair and replication proteins in aging and obesity.

Efficient mechanisms for genomic maintenance (i.e., DNA repair and DNA replication) are crucial for cell survival. Aging and obesity can lead to the dysregulation of genomic maintenance proteins/pathways and are significant risk factors for the development of cancer, metabolic disorders, and other genetic diseases. Mutations in genes that code for proteins involved in DNA repair and DNA replication can also exacerbate aging- and obesity-related disorders and lead to the development of progeroid diseases. In this review, we will discuss the roles of various DNA repair and replication proteins in aging and obesity as well as investigate the possible mechanisms by which aging and obesity can lead to the dysregulation of these proteins and pathways. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Alexandra M D'Amico, Karen M Vasquez. The multifaceted roles of DNA repair and replication proteins in aging and obesity. DNA repair. 2021 Mar;99:103049

Mesh Tags

PMID: 33529944

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