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    Carbohydrates, one of the most abundant and widespread biomolecules in nature, play indispensable roles in diverse biological functions, and represent a treasure trove of untapped potential for pharmaceutical applications. Here, we provide a brief overview of carbohydrate-based drug development (CBDD) over the past two decades. More importantly, advanced techniques and methodologies related to CBDD are emerging, including enzymatic synthesis, metabolic engineering, site-specific glycoconjugation, carbohydrate libraries and microarrays as well as carbohydrate-gut microbiome evaluation. These technologies have dramatically accelerated the speed of CBDD. The recently approved drugs and emerging techniques summarized herein will inspire new sights into potential opportunities to discover novel carbohydrate drugs. Copyright © 2021 Elsevier Ltd. All rights reserved.


    Lin Pan, Chao Cai, Chanjuan Liu, Di Liu, Guoyun Li, Robert J Linhardt, Guangli Yu. Recent progress and advanced technology in carbohydrate-based drug development. Current opinion in biotechnology. 2021 Jun;69:191-198

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    PMID: 33530023

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