Protection by the calcium antagonist Wy-47,037 against stress ulceration in the rat.

S T Nielsen, T S Sulkowski

Department of Experimental Therapeutics, Wyeth Laboratories, Inc., Philadelphia, PA 19101.

Pharmacology, biochemistry, and behavior 1988 Jan

filter terms:

Wy-47,037, a novel compound with both intracellular and extracellular calcium-blocking properties, was evaluated for its effects on cold/restraint stress induced ulceration in the rat. Wy-47,037 dose-dependently inhibited ulcerogenesis; with an ED50 of 8 mg/kg, PO, it was approximately twice as potent as nitrendipine (ED50 = 15 mg/kg). Wy-47,037 also reduced basal gastric acid secretion (ED50 = 7 mg/kg) and gastrointestinal motility (ED50 = 16 mg/kg). It is thus possible that Wy-47,037's alteration of basal gastric acid secretion and/or of gastrointestinal motility may contribute to its therapeutic efficacy against stress induced ulcer formation.

Citation

S T Nielsen, T S Sulkowski. Protection by the calcium antagonist Wy-47,037 against stress ulceration in the rat. Pharmacology, biochemistry, and behavior. 1988 Jan;29(1):129-32