Correlation Engine 2.0
Clear Search sequence regions


  • humans (1)
  • peptides (6)
  • peptides c (1)
  • Sizes of these terms reflect their relevance to your search.

    Tumor-homing peptides are widely used for improving tumor selectivity of anticancer drugs and imaging agents. The goal is to increase tumor uptake and reduce accumulation at nontarget sites. Here, we describe current approaches for tumor-homing peptide identification and validation, and provide comprehensive overview of classes of tumor-homing peptides undergoing preclinical and clinical development. We focus on unique mechanistic features and applications of a recently discovered class of tumor-homing peptides, tumor-penetrating C-end Rule (CendR) peptides, that can be used for tissue penetrative targeting of extravascular tumor tissue. Finally, we discuss unanswered questions and future directions in the field of development of peptide-guided smart drugs and imaging agents.

    Citation

    Prakash Lingasamy, Tambet Teesalu. Homing Peptides for Cancer Therapy. Advances in experimental medicine and biology. 2021;1295:29-48

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 33543454

    View Full Text