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Circadian rhythm disorder caused by lack of sleep, day-night reversal, or staying up late, can cause irreparable damage to the body, a significant increase in both the systolic and diastolic blood pressure of women in this age bracket. The purpose of this study was to investigate the effects of circadian disruption on body composition and insulin resistance in women aged 31-40 years. Thirty female with circadian rhythm disorder and employed of the Foot Bath Club in Qufu city were selected as the research subjects, and a body composition analyzer was used to test the subjects' body composition using bioelectrical impedance analysis. Serum melatonin (MT) levels were determined by enzyme-linked immunosorbent assay (ELISA), and blood glucose and insulin levels were detected by glucose oxidase and chemiluminescence assays, respectively. The results showed that circadian rhythm disorder caused a rise in blood pressure, whereas body water, especially lower limb water and intra- and extracellular fluid, decreased significantly. Circadian disruption also resulted in decreased muscle mass, protein quality, and melatonin production, but increased visceral fat levels and insulin resistance. This study has demonstrated that circadian rhythm disorders are responsible for changes in body composition, melatonin levels, and insulin resistance in women aged 31-40 years and may be a risk factor for cardiovascular disease and diabetes.


Ran Meng, Yidan Cao, Yong Kong, Kai Wang, Zengkun Yang, Yingying Jia, Chen Dong, Haiyun Duan, Mengshu Han. Effects of circadian rhythm disorder on body composition in women aged 31-40 years. Annals of palliative medicine. 2021 Jan;10(1):340-349

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PMID: 33545769

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