Synthesis and characterization of biodegradable and antioxidant phosphazene-tannic acid nanospheres and their utilization as drug carrier material.

Alper Onder, Hava Ozay

Materials science & engineering. C, Materials for biological applications 2021 Jan

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In this study, hexachlorocyclotriphosphazene (HCCP) and tannic acid (TA) were used at different stoichiometric ratios to synthesize cyclomatrix-type polymeric materials with different surface features and dimensions. Using different reactive ratios, the structure and surface functional groups of the synthesized polymeric particles were explained using Fourier-Transform Infrared Spectroscopic (FTIR), Scanning Electron Microscope (SEM), Energy-dispersive X-ray spectroscopy (EDX), X-ray Photoelectron Spectroscopy (XPS) and Thermogravimetric (TG) analysis techniques. With morphologically fully spherical structure and mean 234.82 ± 49.37 nm dimensions, Phz-TA (4:1) nanospheres were researched for in vitro biodegradability, antioxidant features, and usability as a drug release system. In vitro biodegradability of Phz-TA (4:1) nanospheres was investigated at pH = 7.0 and pH = 1.2. Determined to degrade in 8-10 h at these pH values, nanospheres were used for releasing of Rhodamine 6G as a model drug. Due to the rich phenolic structure of the contained tannic acid units, nanospheres were determined to simultaneously have antioxidant features. Thus, this study determined that Phz-TA nanospheres with in vitro biodegradability and antioxidant features are promising polymeric materials for use as a potential drug-carrier in the future. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Alper Onder, Hava Ozay. Synthesis and characterization of biodegradable and antioxidant phosphazene-tannic acid nanospheres and their utilization as drug carrier material. Materials science & engineering. C, Materials for biological applications. 2021 Jan;120:111723